TY  - JOUR
T1  - Combination Therapy with rhGM-CSF Gel and Collagen Sponge for Pediatric Deep Dermal Burns: A Randomized Clinical Study
A1  - James Walker
A1  - Olivia Harris
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2025
VL  - 5
IS  - 2
DO  - 10.51847/tYleScIujh
SP  - 187
EP  - 193
N2  - The goal of this investigation was to assess the therapeutic benefits of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) gel, medical collagen sponge, and the joint application of rhGM-CSF gel together with medical collagen sponge on deep second-degree burns affecting the head, face, or neck in infant patients. 108 infants presenting with deep second-degree burns on the head, face, or neck were assigned by random allocation to one of three arms: an rhGM-CSF arm, a medical collagen sponge arm, and an arm receiving rhGM-CSF combined with medical collagen sponge. Comparisons and analyses were performed for the time required for scab dissolution, the duration of wound closure, the rate of positive bacterial cultures, and the Vancouver Scar Scale ratings. The analyzed data indicated that both the period for scab dissolution and the time to wound healing were reduced in the combination arm relative to the rhGM-CSF alone and medical collagen sponge alone arms, with the observed difference reaching statistical significance (P < .05). The proportion of positive bacterial findings was also lower in the rhGM-CSF plus medical collagen sponge arm than in the two monotherapy arms (P < .05). At the 3-month follow-up, the measurements on the Vancouver Scar Scale—covering thickness, pliability, pigmentation, and vascularity of the scar—were more favorable in the rhGM-CSF plus medical collagen sponge arm compared with the arms using rhGM-CSF or medical collagen sponge independently (P < .05). Combining rhGM-CSF gel with medical collagen sponge yields marked efficacy in the management of deep second-degree burns of the head, face, or neck among infants. This regimen helps control infection, accelerate scab dissolution and wound repair, and reduce scar overgrowth and abnormal pigmentation, supporting its value for broader clinical adoption and dissemination.
UR  - https://bprmcs.com/article/combination-therapy-with-rhgm-csf-gel-and-collagen-sponge-for-pediatric-deep-dermal-burns-a-randomi-ouzcj4gqzzaq5gz
ER  -