TY  - JOUR
T1  - Effect of Meeting the 1-Hour Bundle Target on Outcomes in Septic Shock
A1  - Degu Regasa
A1  - Tadele Shiberu
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2021
VL  - 1
IS  - 1
DO  - 10.51847/y8eEv5l9JP
SP  - 29
EP  - 34
N2  - This research explored whether completing the 1-hour resuscitation bundle influences clinical outcomes in patients suffering from septic shock. The analysis utilized prospectively gathered data from multiple centers involving individuals who received standardized bundle-based resuscitation in emergency departments. Using multivariable logistic regression, in-hospital mortality was assessed according to whether the 1-hour bundle was fulfilled. Participants were further classified into three subgroups based on completion time to evaluate temporal outcome differences: group 1 (≤1 hour, reference), group 2 (1–3 hours), and group 3 (3–6 hours). Among the 1,612 patients included, only 461 (28.6%) achieved bundle completion within the first hour. Statistical evaluation showed that completing the 1-hour bundle did not significantly reduce in-hospital mortality when compared to those exceeding one hour (odds ratio = 0.74, p = 0.091). Conversely, meeting the 3-hour and 6-hour bundle targets was linked to substantially lower mortality odds (3 hours and 6 hours; odds ratio = 0.604 and 0.458, respectively). No significant mortality variation was observed between groups 2 and 3 compared with the reference group. The findings indicate that adherence to the 1-hour bundle alone may not yield better survival outcomes in septic shock, underscoring the necessity for additional studies to clarify its clinical importance.
UR  - https://bprmcs.com/article/effect-of-meeting-the-1-hour-bundle-target-on-outcomes-in-septic-shock-7mrcnhcw0lod2w6
ER  -