%0 Journal Article
%T Effect of Vanillic Acid and Morin on Bisphenol S and Diethyl Phthalate Induce-Nephrotoxicity in Male Rats
%A Ofem Effiom Eteng
%A Nseobong Bassey
%A Eteng Ibiang Eteng
%A Ekam Patrick Okwe
%A Grace Ekpo
%A Victor Ekam
%A Eyong Ubana
%J Bulletin of Pioneering Researches of Medical and Clinical Science
%@ 3006-2659
%D 2023
%V 2
%N 1
%R 10.51847/JipHmYy6fi
%P 25-34
%X Endocrine disruptor chemicals (EDCs) have an external influence that has a detrimental effect on the biological system. Morin and vanillic acid has key nephron-pharmacological effects to reduce this effect. We used a rat model to study the impact of Morin and vanillic acid on diethyl phthalate (DEP) and bisphenol S (BPS)- induced nephrotoxicity. After twenty-one days of DEP (50 mg/kg) and BPS (200 mg/kg) exposure and treatment with Morin and vanillic acid (25 and 25 mg/kg), samples were taken for the evaluation of biochemical parameters, including glutathione peroxidase (GPx), glutathione (GSH), catalase activity (CAT), and superoxide dismutase (SOD). Levels of calcium, sodium, urea, and creatinine. Nitric oxide (NO), hydrogen peroxide H202, and malondialdehyde levels (MDA) respectively. The kidney membrane was considerably (P< 0.05) preserved by morin and vanillic acid therapy. In a strikingly significant way (P 
%U https://bprmcs.com/article/effect-of-vanillic-acid-and-morin-on-bisphenol-s-and-diethyl-phthalate-induce-nephrotoxicity-in-male-v4e8nuhqwuedm6y