TY  - JOUR
T1  - Green Synthesis of Silver Nanoparticles with Picrasma javanica Extract Shows Enhanced Wound Healing in Wistar Rats
A1  - Probin Kr Roy
A1  - Fanai Lalchuangkima
A1  - Bikash Gupta
A1  - Z Zonuntluangi
A1  - L Laldinchhana
A1  - Hauzel Lalhlenmawia
A1  - Sanjay Dinkar Sawant
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2023
VL  - 2
IS  - 1
DO  - 10.51847/6wXPZcGzxu
SP  - 35
EP  - 48
N2  - Silver and various non-antibiotic alternative therapies were not utilized after the discovery of penicillin and other antibiotics. However, recently silver has gained substantial recognition due to the rise of antibiotic-resistant strains and its limited propensity to develop resistance. Studies have suggested that Silver nanoparticles (AgNPs) prepared by green synthesis have superior wound-healing properties compared to conventional AgNPs despite the latter having improved mechanical properties and being widely used as wound-healing agents. In our study, we have formulated AgNPs using a green synthesis method using methanolic extract of Picrasma javanica (MePJ) leaves and evaluate its wound healing efficacy in Wistar rats. Prior to formulation, MePJ was evaluated for phytochemical screening, total phenolic and flavonoid content, and antioxidant, antimicrobial, and anti-inflammatory activity. Synthesis of the AgNPs was done by a green synthesis method where 1% MePJ was used as a reducing agent. A UV-visible spectrophotometer was used to characterize the formed AgNPs. Formulated AgNPs were then incorporated in gel and further characterized for pH, porosity, Viscosity, spreadability, extrudability, antimicrobial activity, and wound healing by excision wound model in Wistar rats using 10% w/w povidone iodine ointment as standard. Formulated AgNPs show good physical characteristics, good antimicrobial activity, and enhanced wound closing compared to MeJP gel and povidone iodine ointment. The epithelization period of the wound decreased in AgNPs compared to Povidone iodine ointment. In conclusion, AgNPs have shortened the wound-closing period and may be utilized as an alternative formulation for wound healing‎.
UR  - https://bprmcs.com/article/green-synthesis-of-silver-nanoparticles-with-picrasma-javanica-extract-shows-enhanced-wound-healing-nzwypsujbbr8jnc
ER  -