TY  - JOUR
T1  - Impact of Supervised Exercise Training on HDL Cholesterol Efflux Capacity in Post-Myocardial Infarction Patients
A1  - Wei Chen
A1  - Li Zhang
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2024
VL  - 4
IS  - 1
DO  - 10.51847/3ybSiHYz18
SP  - 158
EP  - 167
N2  - A reduced incidence of cardiovascular events has been linked to high-density lipoprotein (HDL), with patient prognosis additionally shaped by its functional properties. While physical training is a vital measure for improving outcomes in the post-infarction (MI) cohort, the extent to which exercise modulates HDL function remains poorly defined. Sixty-two individuals suffering from acute MI were allocated at random to either a 12–14 week supervised exercise regimen (exercise group—EG) or a control condition (CG). The central goal of the investigation was to assess the impact of exercise on the movement of esterified cholesterol (EC) and unesterified cholesterol (UC) into HDL. Across the full cohort, the starting average velocity of EC transfer to HDL was 2.53 ± 0.83, rising to 2.74 ± 0.64 (P = 0.03) by the conclusion of follow-up. For UC, the analogous readings were 4.08 ± 1.2 initially and 4.4 ± 1.06 subsequently (P = 0.02). The net shift (follow-up less baseline) in EC equaled 0.15 ± 0.84 in the control arm and 0.27 ± 0.69 in the exercise arm (P = 0.53); regarding UC, the shifts came to 0.28 ± 1.14 and 0.35 ± 0.96 (P = 0.80) for the control and exercise arms, respectively. Among post-MI subjects, a 12–14-week course of supervised physical training failed to improve HDL function.
UR  - https://bprmcs.com/article/impact-of-supervised-exercise-training-on-hdl-cholesterol-efflux-capacity-in-post-myocardial-infarct-vzuxil3zrs5qpvt
ER  -