%0 Journal Article
%T Increased Arterial Stiffness and Galectin-3 Expression in Acromegaly: Associations with IGF-1 and Cardiovascular Risk
%A Daniel Fischer
%A Laura Meier
%A Thomas Braun
%A Stefan Koch
%A Felix Roth
%J Bulletin of Pioneering Researches of Medical and Clinical Science
%@ 3006-2659
%D 2024
%V 4
%N 2
%R 10.51847/radS8dP7fN
%P 152-158
%X Secretion of insulin-like growth factor-1 (IGF-1) and growth hormone is heightened in acromegaly, a persistent illness. We aimed to examine the association between carotid femoral pulse wave velocity (CF-PWV) and circulating galectin-3 concentration in subjects with acromegaly. This molecule is hypothesized to be modified in the context of incipient inflammation and atherosclerotic changes. Our work was conceived as a prospective, single-center cross-sectional investigation. The study enrolled 40 healthy controls and 40 patients with recently diagnosed acromegaly, all aged 18-65 years, at Adana City Training and Research Hospital. IGF-1, growth hormone, hemogram, and biochemistry panels were analyzed for the participants. Ready-to-use human galectin-3 assay kits, together with the Enzyme-Linked Immunosorbent Assay technique, were used to quantify galectin-3 concentrations. Subjects were evaluated for CF-PWV by means of Doppler ultrasonography paired with simultaneous electrocardiography. Our data demonstrated that acromegaly cases exhibited elevated values of the fibrotic and inflammatory mediator galectin-3 alongside CF-PWV, the benchmark metric for arterial wall rigidity. In the correlation testing, we detected a relationship between circulating galectin-3 concentration and both IGF-1 levels and CF-PWV readings. Galectin-3 may serve as a novel biomarker to identify and predict the course of cardiovascular disease in acromegaly patients, as well as a molecular target for managing the progression of this pathology.
%U https://bprmcs.com/article/increased-arterial-stiffness-and-galectin-3-expression-in-acromegaly-associations-with-igf-1-and-ca-hifokzcjzidtphh