TY  - JOUR
T1  - Induction of IL-10-Secreting, Filtrate-Reactive T Cells Following Sterile Fecal Microbiota Transplantation in Ulcerative Colitis
A1  - Sung Min Kim
A1  - Jae Hoon Lee
A1  - Soo Min Lee
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2022
VL  - 2
IS  - 2
DO  - 10.51847/Rcy3hWJ8ut
SP  - 106
EP  - 117
N2  - Ulcerative colitis is a long-lasting, immune-driven condition of uncertain origin, occurring across various age groups and markedly impairing daily functioning. Current therapeutic strategies predominantly rely on anti-inflammatory agents and do not specifically target the underlying pathogenic mechanisms. In this work, we examined how transferring a sterile filtrate of stool from healthy individuals influences the activation of anti-inflammatory immune pathways. We found that this intervention in ulcerative colitis patients led to the emergence of T helper cells in circulation that recognized components of the sterile filtrates in an antigen-dependent fashion and secreted IL-10. In contrast, cells obtained from the same individuals prior to treatment responded weakly to these filtrates and mainly released IL-4, reflecting a more pro-inflammatory profile. These findings indicate that transplantation of a sterile stool filtrate promotes a shift toward an anti-inflammatory T-helper phenotype, an effect that strengthened and remained detectable for at least three months following the procedure.
UR  - https://bprmcs.com/article/induction-of-il-10-secreting-filtrate-reactive-t-cells-following-sterile-fecal-microbiota-transplan-munuskgzwzfzry9
ER  -