TY  - JOUR
T1  - Inflammation, Malnutrition, and Oxidative Stress as Predictors of Mortality in Advanced Chronic Kidney Disease (CKD) and Hemodialysis Patients
A1  - Ali Hassan
A1  - Noor Siddiqui
A1  - Bilal Khan
A1  - Sana Malik
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2025
VL  - 5
IS  - 2
DO  - 10.51847/3M5wT4sTrG
SP  - 235
EP  - 242
N2  - Cardiovascular disorders arise with high frequency among individuals suffering from chronic kidney disease and constitute the predominant cause of death within this group. The objective of this investigation was to explore the influence of inflammatory processes, nutritional deficits, and oxidative imbalance in subjects managed with long-term hemodialysis, kidney allograft recipients, or those classified with advanced chronic kidney disease (CKD), along with corresponding outcomes tracked over a 38-month observation window. The cohort comprised 137 participants with impaired renal function (48 were CKD-stage patients, 29 were transplant recipients, 60 CKD subjects were treated with hemodialysis [HD], and 39 healthy volunteers served as the reference group; average age 49 ± 20 years, 96 men and 80 women). Every renal-compromised participant underwent dialysis three times per week, with each session lasting 4 to 5 hours (treatment commenced in March 2017 and extended over 38 months). Biochemical markers, Paraoxonase (PON)-1 function, and indicators of inflammation were quantified following established institutional procedures. Cumulative survival among CKD participants was estimated using the Kaplan–Meier method, with log-rank testing. Individuals of advanced age had a greater probability of developing CKD than the reference group (P < .001). Serum albumin, body mass index, and total cholesterol were lower, whereas triglyceride concentrations were elevated in the HD subgroup (P < .05 across all comparisons). The HD subgroup demonstrated greater PON-1 enzymatic function than the kidney transplant subgroup (P < .001). The healthy reference group exhibited superior PON-1 function compared with the HD, CKD-only, and transplant subgroups (P < .001 for all contrasts). Throughout the 38-month observation of 16 CKD individuals, 15 HD-treated participants died owing to cardiovascular events, and a single individual underwent kidney transplantation. At the 8- to 10-month follow-up, the survival rate reached 85%. With advancing illness, the survival rate fell to 30%, a decline attributed to nutritional depletion among CKD participants. Lipid peroxidation and the malnutrition–inflammation complex are linked across the different stages of CKD. As renal disease advances, biomarkers reflecting lipid peroxidation and malnutrition–inflammation display a consistent upward trajectory.
UR  - https://bprmcs.com/article/inflammation-malnutrition-and-oxidative-stress-as-predictors-of-mortality-in-advanced-chronic-kidn-vbzobjjqhrxbk1p
ER  -