TY  - JOUR
T1  - Predictive Value of TAPSE/PASP Ratio for Clinical Outcomes in MitraClip Recipients
A1  - Burcu Ilgaz
A1  - Bisrat Hailemeskel
A1  - Turkan Pasinlioglu
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2023
VL  - 3
IS  - 1
DO  - 10.51847/yZdAFOj5Yp
SP  - 81
EP  - 89
N2  - For patients with severe mitral regurgitation (MR) who cannot tolerate surgery, transcatheter mitral valve repair (TMVR) has become a dependable therapeutic choice. Despite procedural success, many continue to experience heart failure (HF) admissions and mortality over mid-term follow-up. A growing body of research highlights right ventricular (RV)–pulmonary arterial (PA) interaction as an important determinant of prognosis in HF. This investigation explored whether the tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP) ratio—an echocardiographic index of RV–PA coupling—could predict outcomes in individuals treated with the MitraClip system (Abbott, California, USA). Data were drawn from a multicenter registry of 228 consecutive patients who underwent successful TMVR using MitraClip. Participants were stratified into two cohorts according to a median TAPSE/PASP ratio of 0.35. The principal composite endpoint consisted of all-cause mortality and HF-related readmission. The mean participant age was 72.5 ± 11.5 years, and 154 (67.5%) were men. Subjects with TAPSE/PASP ≤ 0.35 experienced significantly more frequent HF rehospitalizations and deaths (Log-Rank = 8.844, p = 0.003). Multivariate Cox analysis identified TAPSE/PASP, along with the STS Score, as an independent determinant of the composite outcome. The ratio outperformed individual measures of TAPSE or PASP in predictive value. The TAPSE/PASP ratio represents a simple yet powerful non-invasive marker for prognostic assessment in TMVR patients and may enhance both risk evaluation and procedural selection for MitraClip implantation.
UR  - https://bprmcs.com/article/predictive-value-of-tapsepasp-ratio-for-clinical-outcomes-in-mitraclip-recipients-w9pfe3uxk5k51oi
ER  -