%0 Journal Article
%T Simultaneous Estimation of Gender Male and Atrial Fibrillation as Risk Factors for Adverse Outcomes Following Transcatheter Aortic Valve Implantation
%A Junji Tagami
%A Shin-ya Satoh
%A Hirohisa Kano
%J Bulletin of Pioneering Researches of Medical and Clinical Science
%@ 3006-2659
%D 2024
%V 4
%N 2
%R 10.51847/yvaz3NOAQu
%P 69-77
%X As transcatheter aortic valve implantation (TAVI) expands to patients with lower surgical risk, reliable prediction of post-procedural outcomes is increasingly critical. Although the effects of gender and atrial fibrillation (AF) on prognosis have been studied individually, their combined influence remains largely unexplored. This retrospective, multicenter study analyzed 1,088 patients who underwent TAVI between May 2010 and February 2020 at three Japanese hospitals. Participants were classified into four groups based on gender and pre-existing AF: Female without AF (n = 559), Male without AF (n = 266), Female with AF (n = 187), and Male with AF (n = 76). The primary outcome was all-cause mortality, while secondary outcomes included cardiovascular death and a composite of mortality and heart failure hospitalization. Over a median follow-up of 538 days, the Female without AF group experienced the lowest rates of adverse events. Multivariate Cox regression demonstrated that both male sex and AF were independently associated with worse outcomes compared to females without AF (reference), with hazard ratios for all-cause death of 2.7 (Male without AF), 3.5 (Female with AF), and 3.9 (Male with AF). However, no additive or synergistic effect between gender and AF was observed. These findings indicate that male gender and AF each independently predict poorer long-term outcomes after TAVI, without amplifying risk when combined.
%U https://bprmcs.com/article/simultaneous-estimation-of-gender-male-and-atrial-fibrillation-as-risk-factors-for-adverse-outcomes-hbfovjyrkbrdqg7