TY  - JOUR
T1  - Synergistic Action of Hesperidin and Quercetin Modulate the Efficacy of CCl4 -Induced Nephrotoxicity in Rat Model
A1  - Grace Ime Ekpo
A1  - Sampson Ekam Victor
A1  - Ofem Effiom Eteng
A1  - Richard Ebena
A1  - Ndodo Ofonime
A1  - Ezekiel. U. Umoh
A1  - Onofiok Luke Uduak
A1  - Saviour Ufot
A1  - Ubana Eyong
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2023
VL  - 2
IS  - 1
DO  - 10.51847/EYAT8W7hWt
SP  - 49
EP  - 57
N2  - Chemical toxicants are hazardous compounds that can cause oxidative processes that lead to detrimental metabolites for human health when inhaled, consumed, or come into touch with the surface of the skin. Quercetin and hesperidin's effects on carbon tetrachloride (CCl4)-induced nephrotoxicity were examined using a rat model. After being exposed to CCL4 (0.5 mg/kg), rats were gavaged with quercetin and hesperidin (2.4, 2.4, and 1.4 mg/kg each) for twenty-one days. To assess several biochemical indicators, samples were collected. Measurements were made of nitric oxide (NO), hydrogen peroxide (H2O2), and malondialdehyde (MDA). Renal function was assessed using the concentrations of the electrolytes Na, K, Ca, P, and Cl. The levels of GPx (glutathione peroxidase), GSH (glutathione), and CAT (catalase) were measured for antioxidants, and histopathology was also investigated. After being exposed to carbon tetrachloride (CCl4), the concentrations of the electrolytes Na, K, Ca, P, and Cl as well as the histopathological findings increased significantly (P 
UR  - https://bprmcs.com/article/synergistic-action-of-hesperidin-and-quercetin-modulate-the-efficacy-of-ccl4-induced-nephrotoxicity-ptulophz4oipoam
ER  -