%0 Journal Article
%T Temporal Patterns of Antibody-Secreting Cell Recovery Post-Allogeneic Hematopoietic Stem Cell Transplantation
%A Kenji Sato
%A Min Zhang
%A Hana T. Desta
%J Bulletin of Pioneering Researches of Medical and Clinical Science
%@ 3006-2659
%D 2025
%V 5
%N 1
%R 10.51847/1vXoIlqLLu
%P 164-171
%X Immune recovery after stem cell transplantation proceeds in distinct phases. While components of the innate immune system re-emerge quickly, adaptive lymphocytes—particularly T and B cells—require several months to fully reconstitute. In this study, we examined the dynamics and regeneration of newly formed B cells in patients undergoing CD3- and CD19-depleted haploidentical stem cell transplantation combined with additional in vivo T-cell depletion using a monoclonal anti-CD3 antibody. This transplantation strategy provides a unique opportunity to analyze the hierarchy and contribution of specific lymphocyte subsets in vivo without the confounding effects of mTOR or NFAT inhibitors. As anticipated, CD3⁺ T cells and their subsets showed markedly delayed recovery, remaining below 
%U https://bprmcs.com/article/temporal-patterns-of-antibody-secreting-cell-recovery-post-allogeneic-hematopoietic-stem-cell-transp-ovewqhq6chrybjy