TY  - JOUR
T1  - Temporal Patterns of Antibody-Secreting Cell Recovery Post-Allogeneic Hematopoietic Stem Cell Transplantation
A1  - Kenji Sato
A1  - Min Zhang
A1  - Hana T. Desta
JF  - Bulletin of Pioneering Researches of Medical and Clinical Science
JO  - Bull Pioneer Res Med Clin Sci
SN  - 3006-2659
Y1  - 2025
VL  - 5
IS  - 1
DO  - 10.51847/1vXoIlqLLu
SP  - 164
EP  - 171
N2  - Immune recovery after stem cell transplantation proceeds in distinct phases. While components of the innate immune system re-emerge quickly, adaptive lymphocytes—particularly T and B cells—require several months to fully reconstitute. In this study, we examined the dynamics and regeneration of newly formed B cells in patients undergoing CD3- and CD19-depleted haploidentical stem cell transplantation combined with additional in vivo T-cell depletion using a monoclonal anti-CD3 antibody. This transplantation strategy provides a unique opportunity to analyze the hierarchy and contribution of specific lymphocyte subsets in vivo without the confounding effects of mTOR or NFAT inhibitors. As anticipated, CD3⁺ T cells and their subsets showed markedly delayed recovery, remaining below 
UR  - https://bprmcs.com/article/temporal-patterns-of-antibody-secreting-cell-recovery-post-allogeneic-hematopoietic-stem-cell-transp-ovewqhq6chrybjy
ER  -