Although COVID-19 vaccination has been widely implemented, its effectiveness in individuals with asymptomatic or mild infections remains unclear. This study aimed to evaluate the influence of different vaccine types and dosing regimens on isolation duration, discharge rates, viral shedding periods, and the rate of negative test conversion in patients with asymptomatic or mild COVID-19. We analyzed adult patients admitted to Fangcang isolation facilities in Pazhou and Yongning from November to December 2022. Data collected included demographic characteristics, admission records, laboratory results, and vaccination history. A total of 6,560 COVID-19 patients were analyzed (3,584 from Pazhou and 2,976 from Yongning). Among them, 90.6% had received inactivated vaccines, 3.66% recombinant SARS-CoV-2 spike protein subunit vaccines, and 0.91% adenovirus-based vaccines. Of the 6,173 vaccinated individuals, 71.9% had received a booster dose. By day 9, half of the vaccinated patients had completed their isolation, and by day 7.5, 50% of the patients had tested negative. Complete vaccination proved effective in reducing viral persistence and promoting recovery, with heterologous vaccine regimens outperforming inactivated vaccines alone. Nonetheless, no notable differences in protective effects were observed 12 months post-vaccination.
