Written by Marta Torrens
Published in Vol 5 Issue 2, 2025
This study aimed to evaluate the impact of implementing critical value management combined with push short messaging service (SMS) on enhancing the referral rates of patients testing positive for hepatitis C antibody (anti-HCV). Patients with positive anti-HCV results between January 1, 2015, and October 31, 2021, did not receive any specific intervention. From November 1, 2021, to July 31, 2022, patients who tested positive were notified through critical value management and push SMS. For hospi
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Written by Maria Pia Di Palo
Published in Vol 5 Issue 2, 2025
Tobacco consumption continues to be a leading cause of avoidable illness and premature death globally. Digital health interventions have shown substantial benefits in improving clinical outcomes and have demonstrated effectiveness in supporting smoking cessation among the general population, mainly due to their adaptability and capacity for individualized support. Despite this, evidence regarding their efficacy in Asian contexts remains limited. Addressing this gap, the present study seeks to ev
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Written by Carla Sa-Couto
Published in Vol 5 Issue 2, 2025
Cardiopulmonary resuscitation (CPR) is a critical skill in clinical settings, where mistakes can occur and potentially have serious consequences. Common approaches to handling errors include error management (EM) and error avoidance (EA), but their impact on medical performance outcomes is not fully understood. This study examined the effect of framing errors on the outcomes of basic life support (BLS) training for healthcare students. In an equivalence trial with 430 first-year students from me
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Written by Hyerin Gim
Published in Vol 5 Issue 2, 2025
Although COVID-19 vaccination has been widely implemented, its effectiveness in individuals with asymptomatic or mild infections remains unclear. This study aimed to evaluate the influence of different vaccine types and dosing regimens on isolation duration, discharge rates, viral shedding periods, and the rate of negative test conversion in patients with asymptomatic or mild COVID-19. We analyzed adult patients admitted to Fangcang isolation facilities in Pazhou and Yongning from November to De
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Written by Mehmet Emin Arayici
Published in Vol 5 Issue 2, 2025
Adequate sleep is a core human requirement, playing a critical role in maintaining mental and physical health as well as overall life quality. Sleep disruptions are frequently associated with lifestyle factors, including prolonged internet use. Investigating the prevalence of internet gaming disorder among young people in Saudi Arabia and its connection to sleep patterns is therefore essential. This study aimed to explore the relationship between internet addiction and sleep quality among medica
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Written by Qi Zhong
Published in Vol 5 Issue 2, 2025
Although the gut microbiota has been strongly implicated in the development of depression, its precise molecular mechanisms are still poorly understood. This study aimed to clarify the relationship between gut microbial alterations, fluctuations in neurotransmitters, and inflammatory responses in a murine model of depression. A chronic social defeat stress (CSDS) paradigm was used to induce depressive-like states. Fecal samples were analyzed for microbial composition and neurotransmitter levels,
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Written by Majed Alnabulsi
Published in Vol 5 Issue 2, 2025
As air travel rebounds in the post-COVID-19 period, in-flight medical emergencies (IMEs) are anticipated to become more frequent. Despite this, there is limited research assessing the readiness of health profession students to respond to such situations. This study aimed to evaluate medical students’ knowledge, confidence, and willingness to assist in an IME within their internship program. A cross-sectional design was employed using an online, self-administered questionnaire distributed to medi
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Written by Sangiliyandi Gurunathan
Published in Vol 5 Issue 2, 2025
Intracranial aneurysm (IA) is a life-threatening cerebrovascular condition, often fatal when complicated by subarachnoid hemorrhage. While Krüppel-like factor 6 (KLF6) has been implicated in cancer and cardiovascular pathologies, its role in IA remains largely unexplored. The present study aims to clarify KLF6’s involvement in IA and identify potential therapeutic agents, advancing understanding and management of this condition. Gene expression datasets GSE122897 and GSE15629 were retrieved from
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Written by Patrizia Pignatti
Published in Vol 5 Issue 2, 2025
Optimal asthma management focuses on controlling symptoms and preventing exacerbations. While serum and sputum eosinophil counts have traditionally been used to gauge eosinophilic airway inflammation, these measures are invasive and may not always be practical. The fraction of exhaled nitric oxide (FeNO) has emerged as a promising, non-invasive biomarker that reflects airway eosinophilia and may guide timely adjustments in inhaled corticosteroid therapy, particularly in patients with uncontrolle
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Written by Lavinia Davidescu
Published in Vol 5 Issue 2, 2025
Infectious agents are implicated in the development of various cancers, with Helicobacter pylori (H. pylori) frequently detected in gastric cancer patients. This study aimed to evaluate the expression of the SMOX gene in a cohort of Polish gastric cancer patients. SMOX is proposed to facilitate H. pylori-mediated carcinogenesis through mechanisms involving inflammation, DNA damage, and activation of β-catenin signaling. Additionally, we analyzed mRNA expression of selected pro-inflammatory cytok
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Written by Orhan Ozturk
Published in Vol 5 Issue 2, 2025
Therapeutic plasma exchange (TPE) is widely employed in managing various pediatric neuro-immunological disorders. This study aims to evaluate the safety profile and clinical effectiveness of TPE in children. We conducted a retrospective, single-center cohort study including pediatric patients who experienced neuro-immunological events and received TPE at a tertiary referral institution. A total of 81 patients (Guillain-Barre syndrome: 65; other polyneuropathies: 5; myasthenia gravis: 8; multiple
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Written by Katarzyna Szum
Published in Vol 5 Issue 2, 2025
This study aimed to evaluate the presence of anti-SARS-CoV-2 antibodies in the general population and in COVID-19 convalescents six months post-infection. The study included two groups: Group I comprised 232 individuals recovering from COVID-19, and Group II included 544 participants from a population-based cohort. Anti-nucleocapsid (anti-N) antibodies were measured using the Elecsys Anti-SARS-CoV-2 assay, while anti-spike (anti-S) antibodies were assessed using the LIAISON SARS-CoV-2 S1/S2 IgG
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Written by Robert J. Evans
Published in Vol 5 Issue 2, 2025
To assess the impact of canagliflozin, dapagliflozin, ertugliflozin, empagliflozin, and sotagliflozin on glycated hemoglobin (HbA1c) levels in individuals with type 2 diabetes mellitus. Randomized controlled trials enrolling individuals with type 2 diabetes mellitus were retrieved through comprehensive electronic searches of the Web of Science, EMBASE, Cochrane Library, PubMed, and ClinicalTrials databases up to June 2020. Study selection, quality appraisal, and data extraction were independentl
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Written by Kim Da Hye
Published in Vol 5 Issue 2, 2025
Genetic variations in angiogenesis-related genes lead to marked differences among patients in how well they respond to drugs that block new blood vessel formation. In a study of 57 individuals with metastatic colorectal cancer treated with bevacizumab plus chemotherapy, researchers tested 20 single nucleotide polymorphisms (SNPs) in 13 genes from the angiogenesis pathway to find markers that could forecast tumor shrinkage, progression-free survival (PFS), and overall survival (OS). DNA was obtai
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Written by Fabio L. Rizzi
Published in Vol 5 Issue 2, 2025
Since 1994, polymyxin B immobilized fiber columns (PMX) have been used to remove endotoxins in patients with sepsis and septic shock. Over the past 25 years, this therapy has shown clinical benefits, but large, multicenter randomized trials have yet to demonstrate a clear survival advantage. Following results from a major North American sepsis trial, a new study is currently investigating whether PMX can improve long-term survival in septic patients. Additional insights may come from analyzing l
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Written by Miguel A. Torres
Published in Vol 5 Issue 2, 2025
This study explored how dexmedetomidine (Dex) influences perioperative hemodynamics and provides organ protection in children with congenital heart disease (CHD) undergoing open-heart surgery with hypothermic cardiopulmonary bypass. Ninety pediatric patients were randomly divided into three groups (n = 30 each): group C received 0.9% saline at 0.2 μg/kg/hour, group D1 received Dex at 0.2 μg/kg/hour, and group D2 received Dex at 0.4 μg/kg/hour. Anesthesia induction was performed using fentanyl, p
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