This study investigates the association between circular RNA (circRNA) derived from three genes of the ADAMTS family—ADAMTS6, ADAMTS9, and ADAMTS12—and their corresponding host gene expression in non-small-cell lung cancer (NSCLC), considering various clinical parameters. A notable link was observed between ADAMTS12 expression and specific circRNAs, while distinct expression patterns of ADAMTS6 and its associated circRNAs were found to be subtype-specific. Survival analysis revealed that lower ADAMTS6 expression in squamous cell carcinoma correlated with improved survival, higher ADAMTS9 expression was associated with longer survival, and overexpression of ADAMTS12 predicted poorer outcomes. These findings indicate that circRNAs may serve as potential diagnostic or prognostic biomarkers in NSCLC, emphasizing the significance of molecular patterns across different cancer subtypes.
