The clinical trial titled “Effect of Modulated Auditory Stimulation on Interaural Auditory Perception” (NCT0544189) sought to determine whether a specific auditory intervention, “Bérard in 10,” could enhance the benefits of routine treatments for patients experiencing anxiety and/or depression. Unblinded, randomized, controlled clinical trial. Mejorada del Campo Health Center, Madrid (Primary Care). A total of 233 patients were selected via systematic sampling and met the following inclusion criteria: being legally adult and free of severe acute illness or an unstable chronic condition. All participants underwent assessment with the Goldberg and Hamilton scales and were assigned either to the Emotional Well-Being group (EWB, n = 86) or the Anxiety and/or Depression group (AD, n = 147). Precisely half the members of each group underwent the auditory intervention. Participants listened to classical music altered by a frequency modulator (Earducator) designed to dampen irregular frequencies for 30 min per session, delivered twice daily across 5 consecutive days. Scores on the Hamilton Anxiety Scale and Hamilton Depression Scale, recorded at the 3-month and 6-month follow-up points. According to the per-protocol analysis, participants in the EWB group who received the auditory intervention (n = 14) recorded markedly reduced anxiety and depression scores at both 3 and 6 months relative to those in the EWB group who did not receive it (n = 36) (p < 0.05), producing large and moderate effect sizes respectively; similarly, members of the AD group receiving the intervention (n = 31) achieved lower anxiety and depression scores at 3 months and reduced anxiety scores at 6 months compared with the AD group without the intervention (n = 52) (p < 0.05), showing a small effect size. No harmful effects were observed. The auditory intervention “Bérard in 10” proved effective at substantially lowering the risk of developing anxiety and depression symptoms while also providing a modest improvement to the results of standard primary care treatments.
