The present study is a comparison between two Euphorbia hirta specimens collected in Addis Ababa, Ethiopia, and Avadi, Chennai, India to analyze the geographical differences seen in the phytoconstituents. This comparative study deals with both plants' phytochemical screening, FTIR, and GC-MS analysis of Euphorbia hirta. Phytochemical screening of the aqueous, petroleum ether, acetone, methanolic, and ethanolic extracts of both the Euphorbia hirta was done and the results revealed the presence of terpenoids, phlorotannins, tannins, flavonoids, cardiac glycosides, saponins, steroids, alkaloids, quinones, and coumarins. On comparing the results of Eh-E and Eh-I, it is apparent that the ethanol extract of both samples showed the existence of maximum phytochemical compounds. The GC-MS analysis of an aqueous extract of Euphorbia hirta from both continents revealed the presence of 12 and 15 phytoconstituents respectively. The similar chemical components from both regions are phytol and decanoic acid, which were found responsible for the major bioactivity. The study suggests that Euphorbia hirta can be utilized as a potential source of pharmaceuticals and can be further studied in the extraction of particular bioactive compounds.
