Written by Sarita Goyal
Published in Vol 4 Issue 2, 2024
Ulcerative colitis (UC) is a chronic idiopathic disease characterized by an inflammatory response largely limited to the colonic mucosa. Being a lifelong condition, ulcerative colitis has a significant psychological and social impact on patients. Vitamin D can restore the gut mucosal barrier in addition to regulating immunological responses. Vitamin D may improve a patient's quality of life and reduce the symptoms of ulcerative colitis by having an anti-inflammatory impact on the intestines
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Written by P S Samyuktha
Published in Vol 4 Issue 2, 2024
Diabetes mellitus is an endocrine-related systemic metabolic disorder that is characterized by increased blood glucose levels and abnormalities in carbohydrate, protein, and lipid metabolism. Many studies show a high prevalence rate of periodontal diseases as well as increased severity in diabetic patients than in non-diabetic patients, including greater attachment loss, increased alveolar bone loss, marked bleeding on probing, and increased mobility of teeth. The current study aims to evaluate
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Written by Mazen Khalid Alnuwaiser
Published in Vol 4 Issue 2, 2024
The evolution of esthetic restorative materials for anterior teeth has transformed the field of dentistry, driven by the demand for natural-looking and durable dental restorations. This narrative review explores recent advancements in anterior teeth esthetics, focusing on materials, techniques, and technologies. Through a systematic literature search of academic databases, studies published in the last decade were analyzed to highlight innovations in materials such as ceramics, zirconia, resin-b
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Written by Deep Kwatra
Published in Vol 4 Issue 2, 2024
One of the methods of cancer treatment is radiotherapy. Although radiation resistance and toxicity in normal cells limit the use of radiotherapy in some specific anatomical situations, however, together with radiotherapy, the use of substances that increase the radiation sensitivity of cancer cells and at the same time toxicity can be useful if they do not have cells on normal cells. The present study aimed to investigate the radiosensitizing effect of tolmetin in radiotherapy treatment on human
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Written by Mahendra Kumar Sahu
Published in Vol 4 Issue 2, 2024
Aegle marmelos Linn. (Bael) is a fruit-bearing tree native to the Indian subcontinent. It holds a significant place in traditional medicine systems and cultural practices of the region. The aim of the study on A. marmelos phytochemical and pharmacological investigation of the bioactive compounds present in the plant and to elucidate their potential pharmacological activities. The goal of this research is to better understand ancient medicine and its possible uses in contemporary healthcare. A mu
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Written by Bahar Graefen
Published in Vol 4 Issue 2, 2024
Office hours (OH) have long been a staple of university syllabi, intended to provide students with dedicated time to seek help from their instructors. Instructors at Chicago State University (CSU) are required to set aside four hours each week for discussion with students. This approach ensures that students have numerous academic opportunities to ask questions, get help with their assignments. The objective of this study is to identify the students who attend CSU Office hours in immunology and
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Written by Sabin Shrestha
Published in Vol 4 Issue 2, 2024
Fluoroquinolone resistance in uropathogenic Escherichia coli (UPEC) poses a significant challenge in the treatment of urinary tract infections (UTIs), a major global health issue. As resistance rates rise, particularly in developing countries, there is an urgent need for novel derivatives. This study aims to explore fluoroquinolone resistance in UPEC isolates and identify potential lead compounds using in-silico methods to optimize fluoroquinolone derivatives that may overcome resistance. A retr
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Written by Junji Tagami
Published in Vol 4 Issue 2, 2024
As transcatheter aortic valve implantation (TAVI) expands to patients with lower surgical risk, reliable prediction of post-procedural outcomes is increasingly critical. Although the effects of gender and atrial fibrillation (AF) on prognosis have been studied individually, their combined influence remains largely unexplored. This retrospective, multicenter study analyzed 1,088 patients who underwent TAVI between May 2010 and February 2020 at three Japanese hospitals. Participants were classifie
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Written by Yujie Yi
Published in Vol 4 Issue 2, 2024
Augmented renal clearance (ARC), defined as a creatinine clearance (CrCl) greater than 130 mL/min/1.73 m², is increasingly recognized among critically ill patients, affecting roughly one-third to two-thirds of this population. Standard vancomycin dosing regimens are often inadequate for these individuals, as enhanced renal filtration accelerates drug elimination and leads to subtherapeutic serum concentrations, compromising antimicrobial efficacy. The present review examines how ARC influences v
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Written by Chao Min Cheng
Published in Vol 4 Issue 2, 2024
This study aimed to revalidate determinants influencing the restoration of tongue pressure in older individuals following therapy for head and neck malignancies, utilizing advanced machine learning approaches. Logistic regression, support vector regression, random forest, and extreme gradient boosting models were trained on variables such as age, surgical category, dental condition, and demographic characteristics, derived from detailed patient records and direct tongue pressure measurements. Re
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Written by Mariola Seoane-Gigirey
Published in Vol 4 Issue 2, 2024
Compliance with the use of therapeutic footwear (TF) aimed at preventing diabetic foot ulcers remains notably insufficient. The main goal of this research was to assess public awareness of ulcer formation and/or recurrence risks in relation to footwear selection. The secondary objective was to analyze how patients’ footwear choices align with their individual risk levels. From 1 September 2017 to 31 August 2018, forty podiatrists took part in the study, completing six-section forms that included
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Written by Arifa Saif
Published in Vol 4 Issue 2, 2024
Colorectal cancer (CRC) represents the second most prevalent malignancy among Palestinian patients. Although cancer care services in West Bank hospitals have advanced in recent years, specialized interventions—such as palliative care, targeted therapy, bone marrow transplantation, and personalized treatment—remain limited. This study aimed to evaluate the stages at diagnosis, treatment protocols, and survival outcomes of CRC patients in the West Bank. This retrospective study utilized medical re
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Written by Sven L. Eriksson
Published in Vol 4 Issue 2, 2024
This work explores the bioactive constituents and potential therapeutic mechanisms of Shufeng Jiedu Capsules (SFJDC) against the novel coronavirus using an integrated strategy combining network pharmacology and molecular docking approaches. Chemical constituents of SFJDC were collected from the TCMSP, TCMID, and BATMAN-TCM databases. Candidate active compounds were filtered according to ADME (absorption, distribution, metabolism, and excretion) criteria and structurally confirmed using PubChem,
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Written by Alexander R. Novak
Published in Vol 4 Issue 2, 2024
Acute kidney injury (AKI) occurs in roughly 25% of patients with acute decompensated heart failure (ADHF), representing a sudden loss of kidney function that correlates with higher long-term mortality. Identifying AKI early in ADHF remains a major clinical challenge, as no protein biomarkers currently offer adequate diagnostic or prognostic reliability for routine use. This study sought to uncover new protein biomarkers for AKI in ADHF by profiling kidney protein changes during disease progressi
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Written by William J. Carter
Published in Vol 4 Issue 2, 2024
This study aimed to assess the reliability of an objective diagnostic approach for giant cell tumour of bone (GCTB) by evaluating H3-3A gene mutations through Sanger sequencing and immunohistochemistry (IHC). The cohort comprised 214 patients: 120 diagnosed with GCTB and 94 with other giant cell-rich lesions of bone. Analyses were conducted on formalin-fixed, paraffin-embedded samples, with EDTA-based decalcification applied where required. Sanger sequencing demonstrated 100% sensitivity (95 per
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Written by Chen Hao
Published in Vol 4 Issue 2, 2024
The prognostic determinants for gastric signet ring cell carcinoma (GSRC) remain inadequately characterized. This study aimed to predict survival outcomes in GSRC patients by developing and validating a model incorporating the neutrophil–lymphocyte ratio (NLR). We retrospectively analyzed 147 GSRC patients treated at the Department of Surgical Oncology, Neimenggu Baogang Hospital, Inner Mongolia Medical University. Using Cox proportional hazards regression, a predictive model was constructed, an
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