How to use different methods of blood pressure measurement and familiarity with these methods is necessary to control blood pressure diseases. The new guidelines emphasize the use of appropriate blood pressure measurement techniques. This study compares blood pressure measurement methods with mercury and digital devices and examines the effect of the SPRINT measurement method on blood pressure. In this study, the blood pressure of 87 patients was measured three times in a row at 5-minute intervals in a quiet room, and their average was considered as SPRINT blood pressure. Two of these measurements were done with a mercury device and the third time with a digital device. The resulting numbers were compared with the pressure measured by the digital device in the office and the blood pressure measured by the nurse during the same visit. The findings showed that the systolic blood pressure measured during the visit was about 8.4 mm Hg higher than the blood pressure measured by the SPRINT method (p<0.001). The diastolic blood pressure measured in the office was approximately 7.05 mm Hg higher than the pressure measured by the SPRINT method (p<0.001). According to the results obtained from the present study, the method of measuring blood pressure and the tools used have a significant effect on the numbers obtained and the diagnosis and treatment process. These results show the necessity of complete familiarity with these methods.