The prevalence rate of Musculoskeletal Disorders (MSDs) in Pakistan is 70% more than that in developed countries. This study aims to assess health outcomes in musculoskeletal patients and the role of pharmacists in educating patients to improve Health-Related Quality of Life through extended pharmaceutical services in community pharmacy practice. Patients(n=281) with different musculoskeletal disorders including rheumatoid arthritis, osteoarthritis, gout, and body pain from 10 different community pharmacies responded to questionnaires containing demographics, disease-specific, and assessment of community pharmacy practice questions. Rheumatoid Arthritis (RA) was reported by 33.1% of the patients, 24.6% reported Osteoarthritis (OA), 6% reported gout, and 35.9% reported body pain. The studied population reported moderate to severe pain and other health parameters despite taking various analgesic medications. The patients' quality-of-life scores (poor, moderate, good) were significantly associated with the population demographics and community pharmacist knowledge. Community pharmacists improve the quality of life of musculoskeletal disorder patients by prescription checking, reducing medication errors, and counseling. There is a need for more access to community pharmacies to reduce the burden on healthcare centers. Training sessions should be conducted on comprehensive pharmaceutical services to prevent medication errors.