In developing countries, the first cause of maternal mortality is postpartum hemorrhage. Therefore, prevention and treatment of postpartum hemorrhage is an important step in the health of society, especially the health of women. So far, various studies have tried to suggest the best and most effective way to treat postpartum hemorrhage. The present study was conducted to review the studies conducted on medical and non-medical treatments effective on postpartum hemorrhage in Iran and the world. The information needed in this study was searched from IRCT, Scopus, SID, Google Scholar, Pubmed, and Science Direct databases with the keywords postpartum hemorrhage and clinical trial. Based on the reviews, the number of studies conducted in the field of herbal medicines was very few, but many in the field of chemical medicines. The results showed that oxytocin is used as the first line of treatment for postpartum hemorrhage due to fewer side effects, and the next drug is misoprostol. There is a need for more studies on the effect of other drugs, both medical and non-medical. There are various medical and surgical methods to control bleeding after childbirth, and if correct and timely measures are taken, the need for invasive methods, complications, and maternal mortality will be reduced.
