Written by Fatma Hussein Abdelwahab
Published in Vol 1 Issue 1, 2021
Primary percutaneous coronary intervention (PPCI), a key therapeutic procedure for ST-segment elevation myocardial infarction (STEMI), experienced major disruption during the COVID-19 crisis. This study investigated how the pandemic influenced both the frequency of PPCI procedures and the short-term hospital outcomes of STEMI patients. Using a retrospective observational approach, data were collected from consecutive patients admitted to the International Cardiac Center (ICC) in Alexandria, Egyp
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Written by Qin-Zhe Sun
Published in Vol 1 Issue 1, 2021
Vasoactive and inotropic agents are vital in sepsis treatment, but the link between the peak Vasoactive-Inotropic Score (VISmax) and patient outcomes in adults is not well understood. This study examined whether VISmax could serve as an early indicator of mortality in adult sepsis patients admitted to the emergency department (ED) and compared its predictive ability with the Sequential Organ Failure Assessment (SOFA) score. We conducted a single-center retrospective analysis of 910 sepsis patien
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Written by A. Kankanhalli
Published in Vol 1 Issue 1, 2021
Fenofibrate has been reported to slow diabetic retinopathy (DR), but the precise mechanisms in retinal tissue remain unclear. As an agonist of peroxisome proliferator-activated receptor alpha (PPARĪ±), a key regulator of metabolism, inflammation, and oxidative stress, fenofibrate was hypothesized to protect against early retinal damage through PPARĪ± activation. Using the db/db mouse model of type 2 diabetes, we found that six-month-old diabetic mice showed elevated blood lipids, reactive gliosis
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Written by Degu Regasa
Published in Vol 1 Issue 1, 2021
This research explored whether completing the 1-hour resuscitation bundle influences clinical outcomes in patients suffering from septic shock. The analysis utilized prospectively gathered data from multiple centers involving individuals who received standardized bundle-based resuscitation in emergency departments. Using multivariable logistic regression, in-hospital mortality was assessed according to whether the 1-hour bundle was fulfilled. Participants were further classified into three subgr
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Written by Carlos S. Ardila
Published in Vol 1 Issue 1, 2021
This study examined patterns of kidney replacement therapy (KRT) in Italy, emphasizing disparities linked to gender and place of residence. Using population-level administrative records from Campania between 2015 and 2018, we analyzed the use of haemodialysis, peritoneal dialysis, kidney transplantation, and associated mortality. Across the study period, 11,713 individuals in Campania were receiving KRT. Annual prevalence ranged from 1000 to 1015 patients per million (pmp) for haemodialysis, 115
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Written by Ke Yao
Published in Vol 1 Issue 1, 2021
SARS-CoV-2, the novel coronavirus responsible for the global COVID-19 pandemic, affects individuals across all demographics. Pregnant women have been recognized as a vulnerable population for SARS-CoV-2 infection; however, data on the precise impact of COVID-19 in this group remain limited. To address this, we performed a systematic review summarizing maternal and fetal outcomes in pregnant women with SARS-CoV-2 infection, aiming to characterize obstetric patients based on the country of publica
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Written by Kim Se-En
Published in Vol 1 Issue 1, 2021
Given the heterogeneous nature of cancers, accurate and specific diagnosis necessitates multiplexed biomarker detection. Extracellular vesicles (EVs) have emerged as promising candidates for liquid biopsy biomarkers in cancer due to their molecular cargo. Nevertheless, their nanoscale size poses significant technical challenges, highlighting the need for an efficient and straightforward detection strategy. In this study, we established a single step in situ detection approach capable of simultan
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Written by Michael Joseph Lee
Published in Vol 1 Issue 1, 2021
Accurate, objective methods for tracking recovery after concussion are essential, yet reliable predictors of adolescent outcomes remain limited. Heart rate variability (HRV), reflecting the coordination between central and peripheral nervous systems, may reveal hidden impairments and serve as an early indicator of symptom progression. This study explored the connection between HRV and recovery trajectories in adolescents and evaluated its potential as a prognostic tool. Fifty-five adolescents (a
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