Written by Fatma Hussein Abdelwahab
Published in Vol 1 Issue 1, 2021
Primary percutaneous coronary intervention (PPCI), a key therapeutic procedure for ST-segment elevation myocardial infarction (STEMI), experienced major disruption during the COVID-19 crisis. This study investigated how the pandemic influenced both the frequency of PPCI procedures and the short-term hospital outcomes of STEMI patients. Using a retrospective observational approach, data were collected from consecutive patients admitted to the International Cardiac Center (ICC) in Alexandria, Egyp
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Written by Qin-Zhe Sun
Published in Vol 1 Issue 1, 2021
Vasoactive and inotropic agents are vital in sepsis treatment, but the link between the peak Vasoactive-Inotropic Score (VISmax) and patient outcomes in adults is not well understood. This study examined whether VISmax could serve as an early indicator of mortality in adult sepsis patients admitted to the emergency department (ED) and compared its predictive ability with the Sequential Organ Failure Assessment (SOFA) score. We conducted a single-center retrospective analysis of 910 sepsis patien
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Written by A. Kankanhalli
Published in Vol 1 Issue 1, 2021
Fenofibrate has been reported to slow diabetic retinopathy (DR), but the precise mechanisms in retinal tissue remain unclear. As an agonist of peroxisome proliferator-activated receptor alpha (PPARĪ±), a key regulator of metabolism, inflammation, and oxidative stress, fenofibrate was hypothesized to protect against early retinal damage through PPARĪ± activation. Using the db/db mouse model of type 2 diabetes, we found that six-month-old diabetic mice showed elevated blood lipids, reactive gliosis
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Written by Degu Regasa
Published in Vol 1 Issue 1, 2021
This research explored whether completing the 1-hour resuscitation bundle influences clinical outcomes in patients suffering from septic shock. The analysis utilized prospectively gathered data from multiple centers involving individuals who received standardized bundle-based resuscitation in emergency departments. Using multivariable logistic regression, in-hospital mortality was assessed according to whether the 1-hour bundle was fulfilled. Participants were further classified into three subgr
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Written by Carlos S. Ardila
Published in Vol 1 Issue 1, 2021
This study examined patterns of kidney replacement therapy (KRT) in Italy, emphasizing disparities linked to gender and place of residence. Using population-level administrative records from Campania between 2015 and 2018, we analyzed the use of haemodialysis, peritoneal dialysis, kidney transplantation, and associated mortality. Across the study period, 11,713 individuals in Campania were receiving KRT. Annual prevalence ranged from 1000 to 1015 patients per million (pmp) for haemodialysis, 115
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Written by Ke Yao
Published in Vol 1 Issue 1, 2021
SARS-CoV-2, the novel coronavirus responsible for the global COVID-19 pandemic, affects individuals across all demographics. Pregnant women have been recognized as a vulnerable population for SARS-CoV-2 infection; however, data on the precise impact of COVID-19 in this group remain limited. To address this, we performed a systematic review summarizing maternal and fetal outcomes in pregnant women with SARS-CoV-2 infection, aiming to characterize obstetric patients based on the country of publica
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Written by Kim Se-En
Published in Vol 1 Issue 1, 2021
Given the heterogeneous nature of cancers, accurate and specific diagnosis necessitates multiplexed biomarker detection. Extracellular vesicles (EVs) have emerged as promising candidates for liquid biopsy biomarkers in cancer due to their molecular cargo. Nevertheless, their nanoscale size poses significant technical challenges, highlighting the need for an efficient and straightforward detection strategy. In this study, we established a single step in situ detection approach capable of simultan
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Written by Michael Joseph Lee
Published in Vol 1 Issue 1, 2021
Accurate, objective methods for tracking recovery after concussion are essential, yet reliable predictors of adolescent outcomes remain limited. Heart rate variability (HRV), reflecting the coordination between central and peripheral nervous systems, may reveal hidden impairments and serve as an early indicator of symptom progression. This study explored the connection between HRV and recovery trajectories in adolescents and evaluated its potential as a prognostic tool. Fifty-five adolescents (a
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Written by John M. Randall
Published in Vol 1 Issue 1, 2021
Depression represents a major concern for cancer survivors, and early detection of depressive symptomatology is essential for timely intervention. This work set out to construct and validate a model capable of estimating depression risk in cancer survivors. A total of 2,279 cancer survivors from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Participants were randomly divided into training and validation cohorts at a 7:3 ratio. Independent determinants of depression
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Written by Marco L. De Santis
Published in Vol 1 Issue 1, 2021
Critically ill patients with hematologic malignancies (HM) frequently present with blood-related complications such as thrombocytopenia, coagulopathy, anemia, and leukopenia, which can considerably elevate the risk of both procedural and post-procedural adverse events. This study investigates the safety profile and clinical outcomes of percutaneous dilatational tracheostomy (PDT) in this high-risk population. We conducted a retrospective cohort study of HM patients who underwent PDT at a tertiar
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Written by Hiroshi Yamamoto
Published in Vol 1 Issue 1, 2021
Adenomyosis is a chronic gynecological disorder primarily affecting women of reproductive age, with its underlying causes remaining unclear. In clinical settings, gonadotropin-releasing hormone agonists (GnRH-a), often in combination with other medications, are employed to manage mild to moderate cases. This meta-analysis aimed to assess the therapeutic effectiveness of combining dienogest with GnRH-a in treating adenomyosis and to investigate associated obstetric risk factors. A comprehensive l
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Written by Andrew K. Miller
Published in Vol 1 Issue 1, 2021
Knowledge of the histology, intestinal morphometry, and lymphocyte subpopulations in the upper oesophagogastrointestinal (UEGI) tract of healthy individuals remains limited. This gap presents a challenge for studies investigating UEGI inflammation, which often lack appropriate healthy control groups. Objective: To characterize the histology of the UEGI tract and duodenal lymphocyte subpopulations in healthy volunteers and to examine whether patients with gastroesophageal reflux disease (GERD) co
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Written by Wei Li
Published in Vol 1 Issue 1, 2021
Women diagnosed with ovarian cancer at advanced stages have significantly poorer survival outcomes compared to those diagnosed at early stages, yet early detection remains a major clinical challenge. Recent evidence suggests that genetic variations may serve as potential biomarkers for the early identification of various cancers. In this pilot observational retrospective study, we investigated whether mitochondrial DNA (mtDNA) variations could distinguish the most common ovarian cancer subtype,
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