Volume 5 Issue 1 (2025)

Extended periods of sedentary behavior during pregnancy have been associated with negative health outcomes and unfavorable pregnancy results. This research aimed to pinpoint specific factors that could be targeted in efforts to reduce sedentary behavior among expectant mothers. Out of 103,057 pregnancies documented in the Japan Environment and Children’s Study, 83,733 participants were analyzed after removing repeated enrollments, missing responses, and incomplete outcome data. Sedentary behavio

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Early life adversity has been demonstrated to produce enduring negative effects across a broad spectrum of biopsychosocial domains. These early adverse experiences may have both direct and indirect impacts on cognitive decline and elevate the likelihood of dementia during older adulthood. Understanding the biopsychosocial outcomes linked to early adversity is vital for shaping health policies and fostering healthy cognitive trajectories throughout life. This research investigates how early adver

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The COVID-19 pandemic interrupted immunisation programs globally, undoing previous progress that had brought vaccine-preventable diseases under significant control. This research investigated how the pandemic influenced the uptake of routine child immunisation services in South Africa. A qualitative study was carried out through in-depth interviews with 51 parents or caregivers of children under five who had missed or postponed one or more scheduled immunisation doses between 2020 and 2022. Addi

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Although adolescence marks the onset of many risk factors for non-communicable diseases (NCDs)—including cardiovascular diseases, cancers, diabetes, chronic respiratory conditions, and mental disorders—these are often only considered in relation to adult health. There is limited insight into how various NCD risk factors co-occur and how they may influence mental wellbeing during adolescence. This study investigates how common these risks are, how they cluster, and how they are connected to menta

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The prevalence of overweight and obesity in China is increasing rapidly, making it a pressing issue for academic investigation. This study seeks to assess how marriage influences overweight and obesity among the Chinese population. Data were drawn from the China Family Panel Studies (CFPS), a comprehensive national longitudinal social survey. A total of 44,095 individuals were included in the analysis, utilizing four waves of panel data. Fixed effects regression analysis was employed. Overweight

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Women’s decision-making power concerning modern contraceptive use plays a pivotal role in enhancing its adoption. Nonetheless, in Ethiopia, the available data on this subject remains sparse and inconsistent. This study aimed to determine the prevalence and identify the factors influencing women’s decision-making power on modern contraceptive use in Girawa district, Eastern Ethiopia, between January 1–30, 2024. A community-based cross-sectional survey was carried out among 510 married women using

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In Canada, cannabis consumption has been growing among older adults, particularly throughout the COVID-19 pandemic. This study investigates how loneliness relates to cannabis use in older Canadians during this time. The analysis utilized quantitative data from 2,020 individuals aged 55 and older, gathered through the Canadian Perspectives Survey Series 6, 2021: Substance Use and Stigma During the Pandemic. After accounting for socio-demographic characteristics, social engagement, and pandemic-sp

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Professionals working in emergency departments (EDs) are frequently exposed to intense physical, psychological, and emotional demands, placing them at elevated risk for burnout. This condition, rooted in long-term occupational stress, not only compromises the health of ED staff but also undermines the healthcare system and negatively affects patient outcomes. Utilizing adaptive emotion regulation strategies (ERS) is essential for managing the pressures of clinical environments and minimizing bur

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Chronic kidney disease (CKD) represents an increasing challenge for global health, with marked differences in its impact across various countries and regions. This research focused on evaluating the patterns in CKD incidence, prevalence, mortality, and disability-adjusted life years (DALYs) spanning the period from 1990 to 2019, based on data from the Global Burden of Disease Study. A thorough investigation was carried out to assess the global as well as age-standardized rates of CKD incidence,

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Cefiderocol is a novel cephalosporin–siderophore conjugate antibiotic with significant potential in combating infections caused by multidrug-resistant (MDR) Gram-negative bacilli. Its antibacterial activity remains largely unaffected by most β-lactamases, including metallo-β-lactamases, and—due to its siderophore-mediated uptake—it demonstrates reduced susceptibility to resistance mechanisms such as porin loss or active efflux, compared to other β-lactam agents. This study aimed to evaluate the

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This review explores the potential of optical coherence tomography angiography (OCTA) to assess the radial peripapillary capillary (RPC) network in individuals infected with SARS-CoV-2, with the aim of understanding COVID-19-related microvascular changes in the retina. A comprehensive search of the PubMed database was conducted to identify original research and review articles that utilized OCTA to visualize the RPC network and quantify its parameters in COVID-19 patients. Current evidence sugge

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Stress-related bipolar disorder (BP) is shaped by intricate interactions among genetic, environmental, and clinical factors. Although the FKBP5 gene functions as a central modulator of the stress response and has been linked to several mood disorders, its potential involvement in insomnia during depressive episodes of BP remains insufficiently explored. This study aimed to examine the association between FKBP5 gene variants and insomnia symptoms emerging during depressive episodes in BP. The stu

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Hip osteoarthritis (HOA) involves progressive cartilage breakdown accompanied by synovial inflammation, though the exact histopathological consequences of synovial tissue changes in HOA are not fully understood. This study investigated the expression patterns of iNOS, BCL-2, and MMP-9 within different synovial cell types. A retrospective cohort of 32 patients was analyzed, recording demographic and anthropometric data including age, sex, height, weight, and body mass index. Synovial tissue sampl

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Immune recovery after stem cell transplantation proceeds in distinct phases. While components of the innate immune system re-emerge quickly, adaptive lymphocytes—particularly T and B cells—require several months to fully reconstitute. In this study, we examined the dynamics and regeneration of newly formed B cells in patients undergoing CD3- and CD19-depleted haploidentical stem cell transplantation combined with additional in vivo T-cell depletion using a monoclonal anti-CD3 antibody. This tran

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Extensive research demonstrates that newborn hearing screening (NHS) can substantially lessen the developmental and functional consequences of permanent childhood hearing loss (PCHL), provided it is carried out within systems designed to reach virtually all infants at birth—commonly referred to as Universal Newborn Hearing Screening (UNHS). In two separate resolutions, the World Health Organization (WHO) has urged countries to establish such nationwide screening frameworks and to generate reliab

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This study examined whether the length of antiviral therapy is associated with relapse in patients with gastrointestinal (GI) cytomegalovirus (CMV) disease, with particular attention to identifying factors that predispose patients to recurrence. Patients diagnosed with GI CMV disease at a tertiary care center between January 2008 and April 2019 were retrospectively reviewed. Relapse was defined as a confirmed recurrence of GI CMV disease occurring at least four weeks after completion of the init

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