Written by Miriam Cavero
Published in Vol 5 Issue 1, 2025
Extended periods of sedentary behavior during pregnancy have been associated with negative health outcomes and unfavorable pregnancy results. This research aimed to pinpoint specific factors that could be targeted in efforts to reduce sedentary behavior among expectant mothers. Out of 103,057 pregnancies documented in the Japan Environment and Children’s Study, 83,733 participants were analyzed after removing repeated enrollments, missing responses, and incomplete outcome data. Sedentary behavio
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Written by SangNam Ahn
Published in Vol 5 Issue 1, 2025
Early life adversity has been demonstrated to produce enduring negative effects across a broad spectrum of biopsychosocial domains. These early adverse experiences may have both direct and indirect impacts on cognitive decline and elevate the likelihood of dementia during older adulthood. Understanding the biopsychosocial outcomes linked to early adversity is vital for shaping health policies and fostering healthy cognitive trajectories throughout life. This research investigates how early adver
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Written by Mokhantso Makoae
Published in Vol 5 Issue 1, 2025
The COVID-19 pandemic interrupted immunisation programs globally, undoing previous progress that had brought vaccine-preventable diseases under significant control. This research investigated how the pandemic influenced the uptake of routine child immunisation services in South Africa. A qualitative study was carried out through in-depth interviews with 51 parents or caregivers of children under five who had missed or postponed one or more scheduled immunisation doses between 2020 and 2022. Addi
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Written by Karly I. Cini
Published in Vol 5 Issue 1, 2025
Although adolescence marks the onset of many risk factors for non-communicable diseases (NCDs)—including cardiovascular diseases, cancers, diabetes, chronic respiratory conditions, and mental disorders—these are often only considered in relation to adult health. There is limited insight into how various NCD risk factors co-occur and how they may influence mental wellbeing during adolescence. This study investigates how common these risks are, how they cluster, and how they are connected to menta
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Written by Xuejiao Chen
Published in Vol 5 Issue 1, 2025
The prevalence of overweight and obesity in China is increasing rapidly, making it a pressing issue for academic investigation. This study seeks to assess how marriage influences overweight and obesity among the Chinese population. Data were drawn from the China Family Panel Studies (CFPS), a comprehensive national longitudinal social survey. A total of 44,095 individuals were included in the analysis, utilizing four waves of panel data. Fixed effects regression analysis was employed. Overweight
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Written by Beyan Ahmed
Published in Vol 5 Issue 1, 2025
Women’s decision-making power concerning modern contraceptive use plays a pivotal role in enhancing its adoption. Nonetheless, in Ethiopia, the available data on this subject remains sparse and inconsistent. This study aimed to determine the prevalence and identify the factors influencing women’s decision-making power on modern contraceptive use in Girawa district, Eastern Ethiopia, between January 1–30, 2024. A community-based cross-sectional survey was carried out among 510 married women using
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Written by Selina Espinoza
Published in Vol 5 Issue 1, 2025
In Canada, cannabis consumption has been growing among older adults, particularly throughout the COVID-19 pandemic. This study investigates how loneliness relates to cannabis use in older Canadians during this time. The analysis utilized quantitative data from 2,020 individuals aged 55 and older, gathered through the Canadian Perspectives Survey Series 6, 2021: Substance Use and Stigma During the Pandemic. After accounting for socio-demographic characteristics, social engagement, and pandemic-sp
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Written by Roxana Mihaela Claponea
Published in Vol 5 Issue 1, 2025
Professionals working in emergency departments (EDs) are frequently exposed to intense physical, psychological, and emotional demands, placing them at elevated risk for burnout. This condition, rooted in long-term occupational stress, not only compromises the health of ED staff but also undermines the healthcare system and negatively affects patient outcomes. Utilizing adaptive emotion regulation strategies (ERS) is essential for managing the pressures of clinical environments and minimizing bur
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Written by Vivekanand Jha
Published in Vol 5 Issue 1, 2025
Chronic kidney disease (CKD) represents an increasing challenge for global health, with marked differences in its impact across various countries and regions. This research focused on evaluating the patterns in CKD incidence, prevalence, mortality, and disability-adjusted life years (DALYs) spanning the period from 1990 to 2019, based on data from the Global Burden of Disease Study. A thorough investigation was carried out to assess the global as well as age-standardized rates of CKD incidence,
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Written by Roberto Lozano
Published in Vol 5 Issue 1, 2025
Cefiderocol is a novel cephalosporin–siderophore conjugate antibiotic with significant potential in combating infections caused by multidrug-resistant (MDR) Gram-negative bacilli. Its antibacterial activity remains largely unaffected by most β-lactamases, including metallo-β-lactamases, and—due to its siderophore-mediated uptake—it demonstrates reduced susceptibility to resistance mechanisms such as porin loss or active efflux, compared to other β-lactam agents. This study aimed to evaluate the
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Written by Triantafillos Loutroukis
Published in Vol 5 Issue 1, 2025
This review explores the potential of optical coherence tomography angiography (OCTA) to assess the radial peripapillary capillary (RPC) network in individuals infected with SARS-CoV-2, with the aim of understanding COVID-19-related microvascular changes in the retina. A comprehensive search of the PubMed database was conducted to identify original research and review articles that utilized OCTA to visualize the RPC network and quantify its parameters in COVID-19 patients. Current evidence sugge
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Written by Katherine Sagredo-Olivares
Published in Vol 5 Issue 1, 2025
Stress-related bipolar disorder (BP) is shaped by intricate interactions among genetic, environmental, and clinical factors. Although the FKBP5 gene functions as a central modulator of the stress response and has been linked to several mood disorders, its potential involvement in insomnia during depressive episodes of BP remains insufficiently explored. This study aimed to examine the association between FKBP5 gene variants and insomnia symptoms emerging during depressive episodes in BP. The stu
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Written by Paul W. Harrison
Published in Vol 5 Issue 1, 2025
Hip osteoarthritis (HOA) involves progressive cartilage breakdown accompanied by synovial inflammation, though the exact histopathological consequences of synovial tissue changes in HOA are not fully understood. This study investigated the expression patterns of iNOS, BCL-2, and MMP-9 within different synovial cell types. A retrospective cohort of 32 patients was analyzed, recording demographic and anthropometric data including age, sex, height, weight, and body mass index. Synovial tissue sampl
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Written by Kenji Sato
Published in Vol 5 Issue 1, 2025
Immune recovery after stem cell transplantation proceeds in distinct phases. While components of the innate immune system re-emerge quickly, adaptive lymphocytes—particularly T and B cells—require several months to fully reconstitute. In this study, we examined the dynamics and regeneration of newly formed B cells in patients undergoing CD3- and CD19-depleted haploidentical stem cell transplantation combined with additional in vivo T-cell depletion using a monoclonal anti-CD3 antibody. This tran
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Written by Emily N. Hughes
Published in Vol 5 Issue 1, 2025
Extensive research demonstrates that newborn hearing screening (NHS) can substantially lessen the developmental and functional consequences of permanent childhood hearing loss (PCHL), provided it is carried out within systems designed to reach virtually all infants at birth—commonly referred to as Universal Newborn Hearing Screening (UNHS). In two separate resolutions, the World Health Organization (WHO) has urged countries to establish such nationwide screening frameworks and to generate reliab
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Written by Robert S. Klein
Published in Vol 5 Issue 1, 2025
This study examined whether the length of antiviral therapy is associated with relapse in patients with gastrointestinal (GI) cytomegalovirus (CMV) disease, with particular attention to identifying factors that predispose patients to recurrence. Patients diagnosed with GI CMV disease at a tertiary care center between January 2008 and April 2019 were retrospectively reviewed. Relapse was defined as a confirmed recurrence of GI CMV disease occurring at least four weeks after completion of the init
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Written by Bruno Martins
Published in Vol 5 Issue 1, 2025
A range of transcatheter devices have been introduced for tricuspid valve procedures in recent times. The present investigation sought to examine acute tricuspid annular reshaping following percutaneous leaflet repair with a device designed to bring leaflets together and diminish tricuspid regurgitation (TR). This retrospective cohort analysis included 26 consecutive subjects managed across two institutions. Intraprocedural three-dimensional transesophageal echocardiography was employed to evalu
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Written by Hiroshi Nakamura
Published in Vol 5 Issue 1, 2025
Evidence indicates that the initiation and progression of endometriosis are intimately tied to persistent psychological strain. The precise manner in which sustained stress contributes to metabolic alterations in women with endometriosis has not been elucidated. Our objective was to expose the mechanistic underpinnings of how sustained stress influences endometriosis evolution and, potentially, to formulate candidate biomarkers to gauge the effect of accelerated, persistent stress on endometrios
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Written by Fatima Zahra Amrani
Published in Vol 5 Issue 1, 2025
Colorectal cancer (CRC) is a malignancy with a high propensity for returning after treatment. Ongoing investigations are exploring effective therapeutic avenues for individuals diagnosed with CRC. This study set out to compare the detection of programmed death-ligand 1 (PD-L1) and anaplastic lymphoma kinase (ALK) across stage III and IV CRC cases, and to assess the clinicopathological relevance of their detection. A sample set of 169 stage III and IV CRC tissues underwent immunohistochemical tes
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Written by Claire Dupont
Published in Vol 5 Issue 1, 2025
Pediatric polytrauma constitutes an intricate clinical entity characterized by distinctive attributes and demands during the initial phase of care. The present investigation was designed to evaluate injury characteristics, immediate clinical management, and clinical endpoints among pediatric polytrauma cases treated at a Level I trauma facility. Particular attention was directed toward comparisons across developmental stages and the determination of whether specific injury types serve as prognos
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Written by Ahmed El-Kholy
Published in Vol 5 Issue 1, 2025
The phenomenon of stress wave dispersion can attenuate or corrupt crucial high-frequency components during material testing at high strain rates or blast-loading trials. This study aims to demonstrate the value of applying dispersion compensation in split-Hopkinson pressure bar experiments conducted under various test conditions. For this purpose, a new computational framework, designated 𝚂𝙷𝙿𝙱 _ 𝙿𝚛𝚘𝚌𝚎𝚜𝚜𝚒𝚗𝚐 . 𝚙𝚢 , is constructed. After guiding the reader through an operational overview of 𝚂𝙷𝙿𝙱 _
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Written by Maria Gonzalez
Published in Vol 5 Issue 1, 2025
Hepatocellular carcinoma (HCC) poses considerable therapeutic challenges, given that standard chemotherapies offer only restricted benefit. The mammalian target of rapamycin/sirolimus (mTOR) and microtubules represent two major druggable vulnerabilities in HCC. In this work, we demonstrated that concurrent mTOR inhibition with mTOR inhibitors (everolimus and sirolimus) and the microtubule inhibitor vinorelbine yielded outcomes superior to those of single-agent regimens in HCC PDX models. Our dat
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