Written by Pakiso Makhoahle
Published in Vol 2 Issue 1, 2022
This study was conducted to ensure the safety of laboratory employees and minimize exposure to microorganisms or infections by using the right surface disinfectant after every shift. A sterility test was performed to detect the presence of potential microbial contaminants in the 5% BA, MCA, and saline. The common laboratory surface test microorganisms identified were Acinectobacter lwoffii and Staphylococcus Lentus. The efficacy of the disinfectants against each test organism at a 15 min contact
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Written by Shahzeb Ansari
Published in Vol 2 Issue 1, 2022
Dental fluorosis has a very typical presentation in terms of tooth surface appearance and oral distribution. Overall, there is increasing clinical evidence for reducing the severity of fluorosis during adolescence for all permanent teeth and into early adulthood. The teenagers in Riyadh participated in this cross-sectional study. 383 kids were included through practical sampling after Riyadh's schools were contacted. Fluorosis was found to be 26% prevalent overall, according to the findings.
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Written by Felix Oghenemaro Enwa
Published in Vol 2 Issue 1, 2022
The purpose of this research is to ascertain the prevalence of vaginal infections among females in Delta State across various age groups. Samples from female patients at Delta State's Central Hospitals and from women who visited private labs in Sapele, Abraka, Eku, and Oghara were used in the research. In order to detect vaginal infection, urine and higher vaginal swabs (HVS) were collected from 500 female subjects who had clinical signs of vaginitis. 88% of women had infected vaginal illnes
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Written by Domenico Prisa
Published in Vol 2 Issue 1, 2022
The underlying cellular and molecular mechanisms that trigger atrial fibrillation (AF) remain poorly understood. Previous studies have identified increased Rho kinase (ROCK) expression and elevated phosphorylation of myosin-phosphatase-target subunit-1 (MYPT-1), a marker of ROCK activity, in AF patients. These changes are linked to higher levels of connexin 40 (Cx40), a gap junction protein critical for fast electrical signal propagation in the heart. AF is particularly common in dialysis patien
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Written by Makoto Hosoya
Published in Vol 2 Issue 1, 2022
Colorectal cancer ranks as the fourth most common cause of cancer-related mortality worldwide, making the development of preventive strategies a critical priority. Antioxidants have been considered as potential preventive agents; however, the contribution of their direct radical-scavenging activity to cancer prevention remains uncertain. In this study, we investigated whether NZ-419, a hydroxyl radical scavenger, could suppress colorectal tumorigenesis through direct elimination of reactive oxyg
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Written by Junzheng Yang
Published in Vol 2 Issue 1, 2022
Immune checkpoint inhibitor therapy has emerged as a highly promising approach for cancer treatment by targeting inhibitory pathways that suppress T cell cytotoxic activity. Recent landmark clinical trials have shown that immune checkpoint blockade (ICB) can induce durable anti-tumor responses with manageable toxicity, leading to the approval of eight checkpoint inhibitors across 15 different cancer types. Nevertheless, a significant proportion of patients—up to approximately 85%—exhibit either
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Written by Carina Bona
Published in Vol 2 Issue 1, 2022
Bariatric surgery (BS) remains the most effective strategy for treating obesity, offering notable improvements in cardiometabolic health and promoting remission of type 2 diabetes. The majority of post-surgical fat loss occurs in the subcutaneous adipose tissue (SAT), yet the functional changes within this depot and its precise role in the benefits of BS are still debated. To explore alterations in protein expression and associated molecular pathways in abdominal SAT (aSAT) following weight norm
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Written by Soojin Lee
Published in Vol 2 Issue 1, 2022
Sarcoidosis is a severe inflammatory disorder that can involve multiple organs, particularly the lungs and lymph nodes. Bone marrow-derived mesenchymal stromal cells (MSCs) have the ability to “reprogram” various macrophage populations toward an anti-inflammatory phenotype. This study investigated whether alveolar macrophages from sarcoidosis patients exhibit a similar anti-inflammatory response when co-cultured with MSCs. Bronchoscopy and bronchoalveolar lavage (BAL) were performed on fifteen s
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Written by Claudia Iftode
Published in Vol 2 Issue 1, 2022
Community pharmacists serve as critical frontline healthcare providers during the COVID-19 pandemic, yet their own health-related quality of life (HRQoL) remains underexplored, despite its impact on their professional performance. To assess HRQoL and examine factors influencing COVID-19 vaccination decisions among pharmacists in Romania and Bulgaria, an online survey was conducted from 15th July to 15th August 2020, including 395 participants. Quality of life was measured using the 15D instrumen
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Written by Li Liu
Published in Vol 2 Issue 1, 2022
Currently, there is growing attention toward understanding the biological and microbiological alterations associated with orthodontic therapy. Advances in knowledge of the oral microbiome increasingly enable the identification and characterization of microbial profiles linked to both oral and systemic conditions. This study aims to explore the associations between orthodontic appliances and changes in the composition and quantity of oral microbiota, particularly regarding factors that may predis
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Written by Felipe M. Torres
Published in Vol 2 Issue 1, 2022
Facial palsy (FP) considerably reduces patients’ quality of life, making accurate severity assessment essential for personalized treatment. EMG-based biofeedback has shown potential in enhancing recovery outcomes. This prospective study aimed to identify EMG time series features that can both classify FP severity and inform biofeedback. Surface EMG was recorded from FP patients and healthy controls during three facial movements. Repeated-measures ANOVAs (rmANOVA) examined the effects of MOTION (
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Written by Jonas K. Weber
Published in Vol 2 Issue 1, 2022
As wearable devices become more widespread and technologically advanced, verifying their accuracy is critical to ensure they provide reliable data for practical use. This study investigated how accurately the Garmin fēnix 6 estimates VO2max and measures blood oxygen saturation (BOS) via pulse oximetry in a general population sample. The study included healthy adults, both physically active and sedentary, for VO2max testing (n = 19) and pulse oximetry assessment (n = 22). VO2max values from the f
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Written by Ahmed K. El Sherif
Published in Vol 2 Issue 1, 2022
Inflammatory bowel disease (IBD) involves disruptions in the gut microbial ecosystem, yet research on methanogenic archaea in children is scarce. This study investigated the presence and abundance of total methanogenic archaea and three specific groups—Methanobrevibacter smithii (Mb. smithii), Methanosphaera stadtmanae (Ms. stadtmanae), and the Methanomassiliicoccales order—in the fecal samples of pediatric patients with Crohn’s disease (CD) and ulcerative colitis (UC), considering both active a
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Written by Thomas R. Nguyen
Published in Vol 2 Issue 1, 2022
Heart failure (HF) is a common and serious condition, yet identifying individuals at greatest risk—especially before symptoms appear—remains a challenge. In this study, we introduce and validate a new genetic testing approach designed to predict HF susceptibility, leveraging data from three separate Australian and US cohorts. The first phase utilized the Baker Biobank case–control cohort, revealing 41 genetic variants associated with HF risk through genome-wide association and interaction analys
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