Written by Bahar Graefen
Published in Vol 3 Issue 2, 2023
Resident doctors regularly suffer burnout because of a wide range of issues, including long working hours, high academic requirements, a lack of independence, balancing their workload and familial responsibilities, low benefits, and anxiety over their future. This is particularly problematic since burnout can increase the probability of medical mistakes and decrease the quality of patient care. This study was conducted in Baku, Azerbaijan, and used a descriptive study design to investigate the s
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Written by Xinyi Chen
Published in Vol 3 Issue 2, 2023
One of the significant aspects of the production of proteins is the discussion of their stability and solubility. Studying the stability of proteins and identifying factors that increase their stability, is one of the important and interesting topics in scientific societies. The production of biotech medicinal proteins plays an important role in the fight against diseases. Proteins are stable only in a limited range of temperature and acidity conditions and are very susceptible to physical and c
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Written by Belén Fernández-Castilla
Published in Vol 3 Issue 2, 2023
Health decisions should be according to the evidence from randomized controlled trials. These studies compare two or more effective interventions in a specific situation on the target population. When for a specific clinical problem in randomized controlled trial studies, the effect of at least three effective interventions is examined, meta-analysis can be used to combine the effect of the interventions and obtain a general estimate of that effect size in the target population; while for most c
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Written by Joshua P. Vogel
Published in Vol 3 Issue 2, 2023
In developing countries, the first cause of maternal mortality is postpartum hemorrhage. Therefore, prevention and treatment of postpartum hemorrhage is an important step in the health of society, especially the health of women. So far, various studies have tried to suggest the best and most effective way to treat postpartum hemorrhage. The present study was conducted to review the studies conducted on medical and non-medical treatments effective on postpartum hemorrhage in Iran and the world. T
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Written by Kasuni Weerasinghe
Published in Vol 3 Issue 2, 2023
A huge amount of data is generated annually in the field of medical care and drug diagnosis. With the continuous growth of data storage tools and the smart devices availability in the world, the big data influence will continue to develop. This efficacy has also been transferred to the field of medicine. The current study was conducted to identify the big data applications in the pharmaceutical field. The present study was done in two stages with a combined approach. In the first step, big data
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Written by Tuba Shahid Chaudhry
Published in Vol 3 Issue 2, 2023
In patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS), vasopressors and inotropes are widely used to stabilize circulation. However, their effect on survival remains uncertain. We performed a systematic review of MEDLINE, EMBASE, and CENTRAL through 20 February 2019, including both randomized and observational studies reporting mortality in AMI-related CS. Eligible studies compared patients receiving at least one vasopressor or inotrope with those who did not r
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Written by Jan H. Willmann
Published in Vol 3 Issue 2, 2023
This systematic review and meta-analysis investigated the clinical outcomes of tooth-borne partial and full-coverage fixed dental restorations produced from hybrid polymer–ceramic CAD/CAM materials, with emphasis on biological, mechanical, and esthetic performance. Literature searches were conducted in MEDLINE using a PICOS framework, and randomized controlled trials as well as case-control studies were screened independently by two reviewers with MeSH terms. Study quality and risk of bias were
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Written by Martin A. Katzman
Published in Vol 3 Issue 2, 2023
While kidney transplantation substantially improves patient outcomes, early post-transplant mortality remains a concern. Growth differentiation factor 15 (GDF-15) has recently been explored as a biomarker for predicting mortality in various clinical contexts. This study investigates whether pretransplant GDF-15 levels can serve as a prognostic indicator in kidney transplant candidates. The analysis included 395 recipients with stored serum samples obtained prior to transplantation. The median GD
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Written by Wiktoria Suchy
Published in Vol 3 Issue 2, 2023
Bariatric surgery is now recognized as a powerful therapeutic approach for individuals with morbid obesity who also suffer from non-alcoholic fatty liver disease (NAFLD). Despite its metabolic benefits, postoperative progression or new emergence of non-alcoholic steatohepatitis (NASH) and hepatic fibrosis has occasionally been reported. Caspase-cleaved keratin 18 (ccK18), a byproduct of hepatocyte apoptosis, has been identified as a reliable indicator of liver cell death—an essential process in
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Written by Maria Szymonowicz
Published in Vol 3 Issue 2, 2023
The progression of periodontal disease is influenced by numerous variables, with dysbiotic microbial flora being the most crucial, exhibiting varying levels of pathogenic potential. Swift bacterial colonization within the subgingival niche can substantially alter the clinical presentation of the periodontium. This systematic review highlights the novel application of loop-mediated isothermal amplification (LAMP) for fast, multiplex identification of microorganisms associated with periodontal con
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Written by Lucas P. Meyer
Published in Vol 3 Issue 2, 2023
Although ART has markedly advanced, the likelihood of achieving pregnancy from transferred human embryos remains limited. Presently, embryo evaluation relies largely on morphological characteristics, which provide weak predictive information, as only a small portion of top-graded embryos result in successful pregnancy. Research has suggested that analyzing metabolites in embryo culture media could improve embryo selection. In this investigation, 66 human embryo culture media samples were analyze
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Written by Hyun Woo Park
Published in Vol 3 Issue 2, 2023
We evaluated how well 0.1% RGN-259 eye drops (formulated with the regenerative peptide thymosin ß4) support the resolution of persistent epithelial lesions in individuals diagnosed with Stage 2 or Stage 3 neurotrophic keratopathy. After 4 weeks, full closure of defects was documented in 6 of the 10 participants treated with RGN-259, compared with 1 of the 8 in the placebo arm (p = 0.0656), suggesting a strong therapeutic signal. Additional evidence of benefit was reflected in the significant hea
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Written by Michael T. O'Connor
Published in Vol 3 Issue 2, 2023
The JAK/STAT signaling cascade comprises intracellular proteins through which numerous cytokines and growth factors regulate genes governing cell activation, proliferation, and differentiation. Although disruptions in this pathway have been reported in many inflammatory and autoimmune disorders, studies specifically addressing autoimmune bullous diseases remain scarce. This research aimed to investigate the expression levels of JAK3, STAT2, STAT4, and STAT6 in epithelial lesions from patients wi
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Written by Carlos R. Mendoza
Published in Vol 3 Issue 2, 2023
A distinct group of plasma extracellular vesicles (EVs) that co-isolate with low-density lipoprotein (LDL-EVs) contains proteins involved in coagulation and fibrinolytic pathways. This work examined whether the balance between these hemostatic and fibrinolysis-related proteins within LDL-EVs corresponds to patterns of post-acute myocardial infarction (post-AMI) left ventricular (LV) remodeling, a process that can lead to heart failure. Levels of von Willebrand factor (VWF), SerpinC1, and plasmin
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