Endocrine disruptor chemicals (EDCs) have an external influence that has a detrimental effect on the biological system. Morin and vanillic acid has key nephron-pharmacological effects to reduce this effect. We used a rat model to study the impact of Morin and vanillic acid on diethyl phthalate (DEP) and bisphenol S (BPS)- induced nephrotoxicity. After twenty-one days of DEP (50 mg/kg) and BPS (200 mg/kg) exposure and treatment with Morin and vanillic acid (25 and 25 mg/kg), samples were taken for the evaluation of biochemical parameters, including glutathione peroxidase (GPx), glutathione (GSH), catalase activity (CAT), and superoxide dismutase (SOD). Levels of calcium, sodium, urea, and creatinine. Nitric oxide (NO), hydrogen peroxide H202, and malondialdehyde levels (MDA) respectively. The kidney membrane was considerably (P< 0.05) preserved by morin and vanillic acid therapy. In a strikingly significant way (P <0.05), co-treatment with Morin and vanillic acid reversed DEP+BPS-induced reductions in glutathione levels, CAT, SOD, GPx, and GSH activities, as well as calcium, sodium, urea, and creatinine levels in the kidney, while attenuating DEP+BPS-mediated increases in nephron-oxidative damage markers (MDA, H202, and NO levels). By acting as an antioxidant, scavenger of free radicals, and having nephron-pharmacological effects, morin and vanillic acid in combination at the same acute dosages may prevent DEP and BPS-mediated nephrotoxicity dysfunctions.
