For several years, prostate cancer has increased worldwide, resulting in a decrease in life expectancy in men. Recently, the World Health Organization reported that this clinical pathology was associated with an increased mortality rate in patients aged 60 to > 60 years. This investigation aimed to analyze some statistical data on prostate cancer in Central and northern Mexico (45 to 64; 65 and ˃ 65 years) populations using the Information System of the Ministry of Health of Mexico. Statistical data showed a higher mortality degree in Mexico City compared to Hidalgo, Morelos, Puebla, Querétaro, and Tlaxcala. Other data on mortality in regions of Northern Mexico indicate that the population of Nuevo León had a higher mortality degree compared to California, Southern California, Chihuahua, Coahuila, and Durango. These results may be associated with differences in the population size of each region involved in Central and Northern cities, Mexico, or some specific demographic factors of each city. It is important to mention that it is necessary to analyze other types of risk factors related to prostate cancer development in Mexico, to have a good data system that serves as an axis for population clinical diagnosis.